2025.01.20

【Doctor-Supervised】The Relationship Between Oxidative Stress and Infertility!? Explaining the Benefits of Moderate Exercise

 

“Oxidative stress” is said to negatively affect various parts of the human body.

 

Reactive oxygen species (ROS), the primary cause of oxidative stress, protect the body by eliminating bacteria and other foreign substances. However, when produced excessively, they disrupt the balance with the body’s antioxidant system, damaging healthy cells.

 

If oxidative stress damages sperm or eggs, it can significantly affect pregnancy. Both men and women considering pregnancy should address oxidative stress with accurate knowledge.

 

This article explains the relationship between oxidative stress and infertility, along with actionable ways to reduce the risk.

 

What is the Relationship Between Oxidative Stress and Infertility!?

 

Oxidative stress, which damages cells and tissues, is known to cause various diseases. It also affects reproductive functions, which are essential for pregnancy.

 

Modern lifestyles often make it difficult to maintain healthy eating and regular exercise, leading to excessive ROS production. This imbalance increases oxidative stress levels, establishing a causal link between oxidative stress and infertility.

 

How does oxidative stress impact infertility? Let’s examine the specific effects on men and women.

 

Oxidative Stress Problems Leading to Infertility for Men and Women

 

Pregnancy involves three main steps: ovulation, fertilization, and implantation. Ovulation is the process where a mature egg is released from the ovary. Fertilization occurs when sperm penetrates the egg, forming a fertilized egg. Implantation is when the fertilized egg travels to the uterine lining and embeds itself there.

 

Damage to sperm or eggs during these stages can hinder fertilization and cause infertility.

 

Oxidative Stress Problems in Women

 

The quality of eggs is crucial for successful fertilization. Persistent oxidative stress damages eggs in several ways.

 

For instance, oxidative damage to genetic material within eggs compromises their integrity and quality, a phenomenon referred to as “egg aging.” This reduces the likelihood of successful pregnancy.

 

Oxidative stress also hardens the egg’s membrane, making it more difficult for sperm to penetrate. Unlike other cells, the number of “primordial follicles,” which are the precursors to eggs, is finite. Thus, maintaining the quality of existing eggs is essential.

 

Oxidative Stress Problems in Men

 

Oxidative stress affects erectile dysfunction (ED), sperm motility, and sperm count.

 

ED is primarily caused by poor blood flow to the lower body. Oxidative stress oxidizes LDL cholesterol, forming plaques that narrow blood vessels and reduce blood flow, leading to ED.

 

Mitochondria, responsible for energy production in sperm, are highly vulnerable to oxidative stress. Thus, reducing oxidative stress is vital for maintaining sperm quality and motility.

 

Prolonged exposure to mobile phones in pants pockets can also increase local oxidative stress, negatively impacting sperm quality and motility.

 

Countermeasures Against Oxidative Stress for Infertility

 

To reduce oxidative stress, you must suppress excessive ROS production while enhancing the body’s antioxidant system. Here are some actionable steps:

 

Avoid Smoking and Excessive Drinking

Both activities generate acetaldehyde, which leads to the production of large amounts of ROS.

 

Passive smoke also contains harmful substances that induce oxidative stress, affecting both you and your partner. Quitting smoking and reducing alcohol consumption can help preserve sperm and egg quality.

 

Improve Your Diet

A diet rich in antioxidants, such as vitamins C, E, carotenoids, and polyphenols, can lower oxidative stress. Incorporate colorful vegetables into your meals, such as bell peppers and green leafy vegetables.

 

Reduce high-sugar foods, as they elevate ROS levels. Opt for brown rice or whole grains instead of white rice for lower sugar content.

 

Engage in Moderate Exercise

 

Moderate exercise boosts antioxidant capacity while temporarily raising oxidative stress. Activities like brisk walking for 30 minutes, two to three times a week, are ideal.

 

Choose Scientifically Backed Supplements

 

Many antioxidant supplements are available, but choose those supported by scientific evidence over vague marketing claims or celebrity endorsements.

 

Conclusion

High oxidative stress negatively affects the body, including sperm and egg quality, increasing the risk of infertility.

 

Taking early steps to reduce oxidative stress through lifestyle changes is vital for reproductive health. For more details, contact us for a leaflet summarizing oxidative stress and fertility.