研究成果

発表論文

1.Neuroprotective Effects of a Novel Antioxidant Mixture Twendee X in Mouse Stroke Model.
Momoko Kusaki, Yasuyuki Ohta, Haruhiko Inufusa, et al. J Stroke Cerebrovasc Dis. 2017 Jun;26(6):1191-1196.

2.Clinical and Pathological Benefit of Twendee X in Alzheimer's Disease Transgenic Mice with Chronic Cerebral Hypoperfusion.
Xia Liu, Toru Yamashita, Jingwei Shang, et al. J Stroke Cerebrovasc Dis. 2019 Jul;28(7):1993-2002.

3.Clinical Benefits of Antioxidative Supplement Twendee X for Mild Cognitive Impairment: A Multicenter, Randomized, Double-Blind, and Placebo-Controlled Prospective Interventional Study.
Koh Tadokoro, Ryuta Morihara, Yasuyuki Ohta, et al. J Alzheimers Dis. 2019;71(3):1063-1069

4.Twendee X Ameliorates Phosphorylated Tau, α-Synuclein and Neurovascular Dysfunction in Alzheimer's Disease Transgenic Mice With Chronic Cerebral Hypoperfusion.
Xia Liu, Toru Yamashita, Jingwei Shang, et al. J Stroke Cerebrovasc Dis. 2019 Oct;28(10):104310.

5.世界初の認知症予防の達成(抗酸化研究部門配合剤Twendee Xによる認知症予防達成までの経緯).
楊馥華、田中翔、マーカスマチューシカグライフェンクラウ、et al. Medical Science Digest. 2019 Nov;45(13):788-791.

6.声とアンチエイジング.
平野滋, 犬房春彦, 杉山庸一郎, et al. 日本抗加齢医学会雑誌. 2019;15(2):214-219.

7.Prevention of Cognitive Decline in Alzheimer's Disease by Novel Antioxidative Supplements.
Koh Tadokoro, Yasuyuki Ohta, Haruhiko Inufusa, et al. Int J Mol Sci. 2020 Mar;21(6):1974.

8.世界初の認知症予防の達成 -酸化ストレス・炎症・免疫との関連.
楊馥華、田中翔、マーカスマチューシカグライフェンクラウ、et al. BIO Clinica. Apr 2020;35(4):46-51.

9.世界初の抗酸化剤の認知症予防の達成 −抗酸化剤Twendee Xが超高齢社会に挑む−.
楊馥華、田中翔、マーカスマチューシカグライフェンクラウ、et al. BIO Clinica. Sep 2020;35(10):45-50.

10.抗酸化剤Twendee Xが高齢者医療に挑む -世界初の認知症予防の実現から見る今後の予防医療-.
楊 馥華、田中 翔、マーカス・マチューシカ・グラフェンクラウ、et al. Precision Medicine. May 2021;4(5):447-452.

11.Neuroprotective and Therapeutic Effects of Tocovid and Twendee-X on Aβ Oligomer-Induced Damage in the SH-SY5Y Cell Line.
Xiao Hu, Toru Yamashita, Haibo Yu, et al. Neurodegener Dis. 2021;21(5-6):117-125.

12.Effects of Antioxidant composition Twendee X on side effects of SARS-CoV-2 mRNA vaccine.
Fukka You, Sho Tanaka, Toshikazu Yoshikawa, et al. Brain Supplement. 2022;4:1-6.

13.Antioxidant composition Twendee X may improve long COVID symptoms.
Fukka You, Sho Tanaka, Toshikazu Yoshikawa, et al. Brain Supplement. 2022;4:7-12.

14.Twendee X, a mixed antioxidant supplement, improves cognitive function, coordination, and neurotrophic factor expression in long-term vitamin E-deficient mice.
Koji Fukui, Fukka You, Yugo Kato, et al. J Clin Biochem Nutr. March 2023;72(2):93-100.

15.Considering antioxidant supplements as a means to prevent diseases.
Fukka You, Yoshiaki Harakawa, Haruhiko Inufusa. J Neurosci Neurol Disord. 2023;7:14-16.

16.Anti-oxidant, Twendee X, for maintenance of singing voice.
Shigeru Hirano, Haruhiko Inufusa, Fukka You, et al. Brain Supplement. 2023;5:1-7.

17.Why Does the Antioxidant Complex Twendee X® Prevent Dementia?
Fukka You, Yoshiaki Harakawa, Toshikazu Yoshikawa, et al. Int J Mol Sci. 2023;24(16):13018.

18.Potential of an antioxidant combination Twendee X® to treat depressive disorders.
Fukka You, Yoshiaki Harakawa, Toshikazu Yoshikawa, et al. Arch Depress Anxiety. 2023;9(2):68-71.

19.Controlling Gut Microbiota by Twendee X® May Contribute to Dementia Prevention.
Fukka You, Yoshiaki Harakawa, Toshikazu Yoshikawa, et al. Int J Mol Sci. 2023;24(23):16642.

20.The Effect of Oxidative Stress on the Human Voice.
Shigeru Hirano, Haruhiko Inufusa, Fukka You. Int J Mol Sci. 2024; 25(5):2604.

21.A Blended Vitamin Supplement Improves Spatial Cognitive and Short-Term Memory in Aged Mice.
Fukui K, You F, Kato Y, et al. Int J Mol Sci. 2024; 25(5):2804.

22.A mixed antioxidant supplement improves cognitive function, and coordination in aged mice.
Koji Fukui, Fukka You, Yugo Kato,et al. J Clin Biochem Nutr. 2024;74(2):119-126.

23.The Potential of Twendee X® as a Safe Antioxidant Treatment for Systemic Sclerosis.
Fukka You, Carole Nicco, Yoshiaki Harakawa, et al. Int J Mol Sci. 2024;25(5):3064.

24.Oxidative Stress and Bio-Regulation. International Journal of Molecular Sciences.
Toshikazu Yoshikawa, Fukka You. 2024; 25(6):3360.